Genetic TestsImatinib Resistance Sequence Analysis

• Test Name: Imatinib Resistance Sequence Analysis
• Test Code: 4810

• “Leukemia, Philadelphia chromosome-positive, resistant to imatinib” || Gene: ABL1 (OMIM #: 189980)

• ABL Gene P Loop Mutations
• Gleevec Resistance
• ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1
• TRANSFORMATION GENE: ONCOGENE ABL
• ABELSON STRAIN OF MURINE LEUKEMIA VIRUS; ABL

• Methodology: DNA Sequencing
• Performed: Everyday
• Reported: Wednesdays

• Specimen Collection: Peripheral blood; Bone marrow aspiration material; Bone marrow biopsy material
• Container: Tube with EDTA
• Specimen Volume/Amount: > 3 ml
• Storage/Transport Condition: Refrigerated
• Unacceptable Specimens/Conditions: Serum; Frozen specimens; Hemolyzed specimens; Icterus; Lipemia

• Hemato Oncogenetics
• Pharmacogenetics